Fresh analysis indicates that individuals who stop using new slimming jabs like Mounjaro or Wegovy can put back on lost weight much more quickly than those who stop traditional diet and exercise programs.
Findings released in a leading medical journal points out that while obese individuals often shed a large proportion of their body weight while on the medication, the weight is regained at an estimated rate of 0.8 kg per month after stopping.
"Users using these treatments should be cognizant of the potential of quick rebound weight gain when the therapy is stopped," warns researcher Dr. Susan Jebb.
Such speed of regain implies a reversion to pre-treatment weight in about 18 months.
Analyzing Approaches
The analysis, which looked at dozens of studies involving thousands of patients, compared the effects of the injectable medications with conventional dieting.
Researchers point out that individuals who lose weight through lifestyle changes alone usually have a less rapid weight regain—perhaps 100 grams monthly—once they finish.
Explaining the Fast Rebound
Nutrition scientists believe the mechanism of the drugs is key to understanding the amplified weight return.
GLP-1 drugs mimic a natural hormone called glucagon-like peptide-1, which controls feelings of fullness.
"Sustained high doses of the hormone concentrations several times higher than normal may cause the body to produce less of its endogenous GLP-1, and may also lessen sensitivity to its actions," explained Dr. Adam Collins, a nutrition specialist.
"Withdrawal of this medication means appetite is uncontrolled, making excessive eating far more likely."
An Ongoing Disease?
The NHS recommend the injections for people with obesity-related health risks, accompanied by recommended diet and exercise modifications.
A number of clinicians contend that, due to the high risk of weight regain, the therapy should be considered long-term.
This perspective is supported by pharmaceutical companies, who note that the results "emphasize the persistent nature of excess weight," comparing it to managing conditions like diabetes.
Patient Testimonies
Individuals who have discontinued the jabs describe a intense resurgence of hunger.
"It felt as if a switch activating and you're instantly starving," described a patient.
This difficulty is compounded if individuals have not developed sustainable dietary or behavioural modifications during therapy.
Significant Adoption
Survey data show that millions of people in the UK have tried weight-loss jabs in the past year, with desire continuing to grow.
- Adoption is more common among females compared to men.
- The 40s and 50s age group shows the highest usage rates.
- A large proportion access the drugs through private healthcare rather than the NHS.
Ultimately, experts emphasize that while the jabs are effective tools for shedding pounds, they are not a magic fix and maintained weight loss hinges on integrated behavioural changes.
